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The White House, Located Near SEMO. Historical Gem

Great for family or group vacations and holiday gatherings. Historic charm with large rooms and high ceilings with all the comfort and amenities of a brand new home. Plenty of off street parking. This spacious and unique historic home is completely renovated; like new inside and out. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital and The Pickleball Factory. Centrally located to most of Cape Girardeau. Close to downtown dining and entertainment.

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

Cape Charm is a "charming" 3 BR home in a safe, quiet neighborhood perfectly located next to SEMO, Mercy Hospital, Capaha Park & the historic district - all less than a 7 minute walk! Feel at home in a magnificently cute 3 bedroom home (w/king bed), fully equipped kitchen, living room, dining room, bathroom, & sun room. Free, fast WIFI, a smart TV in the living room & bedroom. It's centrally located to everything! We are experienced hosts with highly rated listings in Florida and Missouri.

Beautiful Sunset Cottage with amazing views

Robinson Farms NxtGen – The Sunset Cottage Experience the charm of modern farmhouse living with a soulful twist. Nestled in the heart of nature, The Sunset Cottage is an exclusive Airbnb retreat that blends clean, stylish design with the peaceful essence of the outdoors. Whether you're planning a small family escape, a girls’ or guys’ weekend, or a romantic getaway, this serene space offers the perfect backdrop for rest, reconnection, and renewal. A timeless getaway with a fresh perspective.

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Guesthouse w/ pool, outdoor fireplace, game room

Bring the whole family to this great place with lots of room for fun and located in a quiet country subdivision with beautiful sunsets and Missouri wildlife. Enjoy a fire and s’mores in the outdoor fireplace or sit by the propane fire feature in the high-top table. S’more essentials are provided. Full-sized washer and dryer for guest use. Game room has Pac-man arcade, ping pong, pool table and air hockey. No parties, no smoking, no pets allowed, no unregistered guests. See parking policy.

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Riverside Getaway | Near Campus & Downtown

Experience early-1900s architecture just steps from Cape Girardeau’s riverfront. This historic home blends original character with modern updates for a comfortable, well-located stay. Tall ceilings, classic trim, and natural light create a warm feel, while reliable Wi-Fi and updated finishes make it practical for weekend visits or longer stays. Whether you’re here for the Riverwalk, a campus event, or time downtown, this retreat offers charm and walkable convenience.

Beautifully Renovated Farmhouse in Jackson, MO

Originally built to be a homestead, it boasts a spring fed pond, creek, several species of nut trees and a history of all natural fruits, vegetables, pork, free-range chicken and grass-fed beef and lamb. A once private property owned by the Strack family, Rusted Route Farms opened to the public for the first time with Jones Heritage Farm and Market. Heritage Farms brought the community to feast with its delectable brunch and a wide variety of all natural goods.

Log Cabin w/ Hot tub - Near Casino & Downtown Cape

THE BEST GETAWAY HERE IN CAPE! Have a relaxing staycation here in Cape Girardeau Perfect for a QUICK GETAWAY for couples, families or friends 5 MINS to the casino, country club and downtown cape Very unique log home with a private bedroom queen size bed, pull-out queen size futon in the living room and twin size hide away SLEEPS 4. Pool table, darts, and a hot tub.There is a large deck and fire pit which has the feel of being in the woods.

Vibrant Tiny Home Retreat | Creek & Fire Pit

Located just steps from a scenic creek and natural rock formations, this colorful tiny home provides direct access to the outdoors. The compact floor plan includes one queen bed, a double loft bed, and a functional kitchenette. Spend afternoons walking the wooded pathway or relaxing on your private front porch. Finish the day at the communal fire pit under the stars. Perfect for those looking to experience nature and tiny homes.